Assay Detail
Binding
CHEMBL884540
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Inhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New selective and potent 5-HT(1B/1D) antagonists: chemistry and pharmacological evaluation of N-piperazinylphenyl biphenylcarboxamides and biphenylsulfonamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.04 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL147503 | — | — | 1 | 8.52 |
| CHEMBL147071 | — | — | 1 | 8.00 |
| CHEMBL146735 | — | — | 1 | 7.43 |
| CHEMBL15928 | GR-127935 | — | 1 | 7.28 |
| CHEMBL359447 | — | — | 1 | 6.40 |
| CHEMBL422504 | — | — | 1 | 6.33 |
| CHEMBL151420 | — | — | 1 | 6.22 |
| CHEMBL151894 | — | — | 1 | 6.16 |
| CHEMBL443762 | — | — | 1 | - |
| CHEMBL151695 | — | — | 1 | - |
| CHEMBL281350 | SB-224289 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL147503 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL147071 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL146735 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL15928 | GR-127935 | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL359447 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL422504 | — | IC50 | = | 467.0 | nM | 6.33 |
| CHEMBL151420 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL151894 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL443762 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL151695 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL281350 | SB-224289 | IC50 | > | 1000.0 | nM | - |