Assay Detail
Binding
CHEMBL884569
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory constant against thrombin
35
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Development of an oxazolopyridine series of dual thrombin/factor Xa inhibitors via structure-guided lead optimization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 35 | 8.46 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL426101 | — | — | 1 | 10.40 |
| CHEMBL198820 | — | — | 1 | 10.40 |
| CHEMBL198735 | — | — | 1 | 10.22 |
| CHEMBL372194 | — | — | 1 | 10.15 |
| CHEMBL197668 | — | — | 1 | 10.10 |
| CHEMBL198978 | — | — | 1 | 9.85 |
| CHEMBL197593 | — | — | 1 | 9.80 |
| CHEMBL197843 | — | — | 1 | 9.60 |
| CHEMBL196315 | — | — | 1 | 9.51 |
| CHEMBL370396 | — | — | 1 | 9.28 |
| CHEMBL198416 | — | — | 1 | 8.92 |
| CHEMBL196733 | — | — | 1 | 8.82 |
| CHEMBL439678 | — | — | 2 | 8.77 |
| CHEMBL194486 | — | — | 1 | 8.77 |
| CHEMBL194414 | — | — | 1 | 8.70 |
| CHEMBL198002 | — | — | 1 | 8.68 |
| CHEMBL198436 | — | — | 1 | 8.64 |
| CHEMBL282837 | — | — | 1 | 8.64 |
| CHEMBL198071 | — | — | 1 | 8.51 |
| CHEMBL198923 | — | — | 1 | 8.48 |
| CHEMBL197773 | — | — | 1 | 8.47 |
| CHEMBL194670 | — | — | 1 | 8.34 |
| CHEMBL197984 | — | — | 1 | 8.34 |
| CHEMBL194560 | — | — | 1 | 8.11 |
| CHEMBL194569 | — | — | 1 | 8.03 |
| CHEMBL194975 | — | — | 1 | 8.00 |
| CHEMBL194316 | — | — | 1 | 7.82 |
| CHEMBL197128 | — | — | 1 | 7.80 |
| CHEMBL199094 | — | — | 1 | 7.60 |
| CHEMBL382296 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL198820 | — | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL426101 | — | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL198735 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL372194 | — | Ki | = | 0.07 | nM | 10.15 |
| CHEMBL197668 | — | Ki | = | 0.08 | nM | 10.10 |
| CHEMBL198978 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL197593 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL197843 | — | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL196315 | — | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL370396 | — | Ki | = | 0.52 | nM | 9.28 |
| CHEMBL198416 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL196733 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL439678 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL194486 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL194414 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL198002 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL282837 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL198436 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL198071 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL198923 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL197773 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL194670 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL197984 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL194560 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL194569 | — | Ki | = | 9.4 | nM | 8.03 |
| CHEMBL194975 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL194316 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL197128 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL199094 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL439678 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL382296 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL372477 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL370762 | — | Ki | = | 670.0 | nM | 6.17 |
| CHEMBL372108 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL371330 | — | Ki | = | 16000.0 | nM | 4.80 |