Assay Detail
Binding
CHEMBL884575
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Inhibition constant against 5-hydroxytryptamine 1A receptor
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Designed multiple ligands. An emerging drug discovery paradigm.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.92 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL268258 | — | — | 1 | 8.70 |
| CHEMBL198045 | — | — | 1 | 8.49 |
| CHEMBL56564 | TROPISETRON | 3.0 | 1 | 8.28 |
| CHEMBL9831 | — | — | 1 | 8.17 |
| CHEMBL114453 | — | — | 1 | 8.08 |
| CHEMBL104229 | — | — | 1 | 7.96 |
| CHEMBL326134 | — | — | 1 | 7.62 |
| CHEMBL124069 | — | — | 1 | 7.57 |
| CHEMBL198072 | — | — | 1 | 7.35 |
| CHEMBL500 | PINDOLOL | 4.0 | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL268258 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL198045 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL56564 | TROPISETRON | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL9831 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL114453 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL104229 | — | Ki | = | 10.9 | nM | 7.96 |
| CHEMBL326134 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL124069 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL198072 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL500 | PINDOLOL | Ki | = | 110.0 | nM | 6.96 |