Assay Detail

CHEMBL884639

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Binding

Inhibitory concentration against prostaglandin G/H synthase 1

ChEMBL ↗

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Target

Prostaglandin G/H synthase 1 (CHEMBL221) ↗

Open DB target context

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Prostaglandin G/H synthase 1 (CHEMBL221) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Prostaglandin G/H synthase 1

CHEMBL221

Anchored from Assay target.

Protein identity Prostaglandin G/H synthase 1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Expert

Target

Prostaglandin G/H synthase 1 (CHEMBL221) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Designed multiple ligands. An emerging drug discovery paradigm.

Morphy R, Rankovic Z.
J Med Chem (2005) 48 : 6523 -6543
PubMed 16220969 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.80	6.80

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL300982	LICOFELONE	2.0	1	6.80
CHEMBL423638	—	—	1	-

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL300982	LICOFELONE	IC50	=	160.0	nM	6.80
CHEMBL423638	—	IC50	>	10.0	nM	-