Assay Detail
Binding
CHEMBL884714
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding to mu opioid receptor by using [3H]DAMGO as radioligand in guinea pig brain minus cerebellum
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Palladium-catalyzed synthesis of C3-substituted 3-deoxymorphines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.11 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70 | MORPHINE | 4.0 | 1 | 8.07 |
| CHEMBL87247 | — | — | 1 | 6.70 |
| CHEMBL85457 | — | — | 1 | 6.28 |
| CHEMBL82576 | — | — | 1 | 6.19 |
| CHEMBL84484 | — | — | 1 | 5.58 |
| CHEMBL442709 | — | — | 1 | 5.48 |
| CHEMBL85089 | — | — | 1 | 5.35 |
| CHEMBL440694 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70 | MORPHINE | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL87247 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL85457 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL82576 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL84484 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL442709 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL85089 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL440694 | — | IC50 | = | 6400.0 | nM | 5.19 |