Assay Detail
Binding
CHEMBL884719
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Inhibitory concentration against endothelin receptor type A
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Designed multiple ligands. An emerging drug discovery paradigm.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.25 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11706 | BMS-248360 | — | 1 | 8.72 |
| CHEMBL539423 | SPARSENTAN | 4.0 | 1 | 8.03 |
| CHEMBL383581 | EDONENTAN | 2.0 | 1 | 8.00 |
| CHEMBL1513 | IRBESARTAN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11706 | BMS-248360 | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL539423 | SPARSENTAN | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL383581 | EDONENTAN | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL1513 | IRBESARTAN | Ki | > | 10000.0 | nM | - |