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Assay Detail

CHEMBL884758

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Binding
Inhibitory constant against human Coagulation factor Xa
25
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Coagulation factor X (CHEMBL244)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Development of an oxazolopyridine series of dual thrombin/factor Xa inhibitors via structure-guided lead optimization.
Deng JZ, McMasters DR, Rabbat PM, Williams PD, Coburn CA, Yan Y, Kuo LC, Lewis SD, Lucas BJ, Krueger JA, Strulovici B, Vacca JP, Lyle TA, Burgey CS.
Bioorg Med Chem Lett (2005) 15 : 4411 -4416
PubMed 16137886 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 25 7.92 9.12

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL198820 1 9.12
CHEMBL196315 1 9.11
CHEMBL198735 1 8.92
CHEMBL372194 1 8.66
CHEMBL197843 1 8.62
CHEMBL194414 1 8.57
CHEMBL194316 1 8.52
CHEMBL198978 1 8.43
CHEMBL426101 1 8.41
CHEMBL197593 1 8.38
CHEMBL370396 1 8.33
CHEMBL198436 1 8.22
CHEMBL194486 1 8.15
CHEMBL196733 1 8.14
CHEMBL198416 1 7.96
CHEMBL198923 1 7.92
CHEMBL439678 2 7.92
CHEMBL194569 1 7.85
CHEMBL197128 1 7.33
CHEMBL197984 1 7.30
CHEMBL194670 1 7.27
CHEMBL198071 1 6.40
CHEMBL372108 1 4.22
CHEMBL194560 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL198820 Ki = 0.75 nM 9.12
CHEMBL196315 Ki = 0.77 nM 9.11
CHEMBL198735 Ki = 1.2 nM 8.92
CHEMBL372194 Ki = 2.2 nM 8.66
CHEMBL197843 Ki = 2.4 nM 8.62
CHEMBL194414 Ki = 2.7 nM 8.57
CHEMBL194316 Ki = 3.0 nM 8.52
CHEMBL198978 Ki = 3.7 nM 8.43
CHEMBL426101 Ki = 3.9 nM 8.41
CHEMBL197593 Ki = 4.2 nM 8.38
CHEMBL370396 Ki = 4.7 nM 8.33
CHEMBL198436 Ki = 6.0 nM 8.22
CHEMBL194486 Ki = 7.0 nM 8.15
CHEMBL196733 Ki = 7.2 nM 8.14
CHEMBL198416 Ki = 11.0 nM 7.96
CHEMBL439678 Ki = 12.0 nM 7.92
CHEMBL198923 Ki = 12.0 nM 7.92
CHEMBL194569 Ki = 14.0 nM 7.85
CHEMBL197128 Ki = 47.0 nM 7.33
CHEMBL197984 Ki = 50.5 nM 7.30
CHEMBL194670 Ki = 54.0 nM 7.27
CHEMBL198071 Ki = 400.0 nM 6.40
CHEMBL439678 Ki = 460.0 nM 6.34
CHEMBL372108 Ki = 60000.0 nM 4.22
CHEMBL194560 Ki > 20.0 nM -