Assay Detail
Binding
CHEMBL884777
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Binding affinity towards mouse spleen cannabinoid receptor 2 using [3H]CP-55940
11
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Spleen |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Potent cannabinergic indole analogues as radioiodinatable brain imaging agents for the CB1 cannabinoid receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.47 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL68641 | — | — | 1 | 8.72 |
| CHEMBL2093080 | — | — | 1 | 8.66 |
| CHEMBL364266 | — | — | 1 | 8.54 |
| CHEMBL370573 | — | — | 1 | 8.28 |
| CHEMBL436120 | — | — | 1 | 8.01 |
| CHEMBL370884 | — | — | 3 | 8.00 |
| CHEMBL1788276 | — | — | 1 | 6.24 |
| CHEMBL196592 | — | — | 1 | 6.10 |
| CHEMBL197257 | — | — | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL68641 | — | Ki | = | 1.91 | nM | 8.72 |
| CHEMBL2093080 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL364266 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL370573 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL436120 | — | Ki | = | 9.8 | nM | 8.01 |
| CHEMBL370884 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL370884 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL370884 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL1788276 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL196592 | — | Ki | = | 790.0 | nM | 6.10 |
| CHEMBL197257 | — | Ki | = | 9600.0 | nM | 5.02 |