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Compound Detail

CHEMBL370884

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Cc1c(C(=O)c2ccccc2I)c2ccccc2n1CC1CCCCN1C

Basic Information

ChEMBL ID CHEMBL370884
Phase Preclinical
Structure Type MOL
InChI Key FPYAVJFDESIWFK-UHFFFAOYSA-N
2
Targets
6
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

472.4
MW (Da)
5.27
ALogP
3
HBA
0
HBD
25.2
PSA (Ų)
0.38
QED
1
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H25IN2O
MW 472.37
Aromatic Rings 3
Heavy Atoms 27
NP-Likeness -0.65

Activity Summary

Ki 6 meas. best 8.17

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Cannabinoid receptor 1
CHEMBL3571
Ki 8.17 7.1867 6.7 3
Cannabinoid receptor 2
CHEMBL5373
Ki 8.0 7.5167 10.0 3

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
16190764 10.1021/jm050135l Cannabinoid receptor 1 3
16190764 10.1021/jm050135l Cannabinoid receptor 2 3

Data from ChEMBL 36 via Core Engine