Assay Detail
Binding
CHEMBL884790
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards 5-HT1A receptor using porcine cortical membrane and [3H]-8-OH-DPAT as radioligand
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and evaluation of 18F-labeled dopamine D3 receptor ligands as potential PET imaging agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.34 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL194727 | — | — | 1 | 7.82 |
| CHEMBL198993 | — | — | 1 | 7.66 |
| CHEMBL197214 | — | — | 1 | 7.62 |
| CHEMBL197162 | — | — | 1 | 7.55 |
| CHEMBL197195 | — | — | 1 | 7.52 |
| CHEMBL194755 | — | — | 1 | 7.29 |
| CHEMBL196744 | — | — | 1 | 7.22 |
| CHEMBL195247 | — | — | 1 | 6.92 |
| CHEMBL59725 | — | — | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL194727 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL198993 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL197214 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL197162 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL197195 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL194755 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL196744 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL195247 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL59725 | — | Ki | = | 360.0 | nM | 6.44 |