Assay Detail
Binding
CHEMBL884794
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Binding affinity towards human alpha-1B adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Bioisosteric phentolamine analogs as potent alpha-adrenergic antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.79 | 7.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL597 | PHENTOLAMINE | 4.0 | 1 | 7.32 |
| CHEMBL362954 | — | — | 1 | 6.99 |
| CHEMBL194849 | — | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL597 | PHENTOLAMINE | Ki | = | 47.4 | nM | 7.32 |
| CHEMBL362954 | — | Ki | = | 102.8 | nM | 6.99 |
| CHEMBL194849 | — | Ki | = | 843.0 | nM | 6.07 |