Assay Detail
Functional
CHEMBL885047
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Inhibitory concentration on GH release from rat pituitary cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Pituitary gland cell |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of iodinated somatostatin analogues selective for hsst2 and hsst5 with excellent inhibition of growth hormone and prolactin release from rat pituitary cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 9.45 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL386909 | — | — | 1 | 10.10 |
| CHEMBL1823872 | SOMATOSTATIN | 3.0 | 1 | 10.00 |
| CHEMBL407676 | — | — | 1 | 10.00 |
| CHEMBL264133 | — | — | 1 | 9.82 |
| CHEMBL269532 | — | — | 1 | 8.96 |
| CHEMBL414316 | — | — | 1 | 7.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL386909 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL1823872 | SOMATOSTATIN | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL407676 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL264133 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL269532 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL414316 | — | IC50 | = | 14.8 | nM | 7.83 |