Assay Detail
Binding
CHEMBL885069
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity against human cathepsin S, using 2 uM of Z -Leu-Arg-AMC as substrate
39
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
A novel class of nonpeptidic biaryl inhibitors of human cathepsin K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 5.75 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL122513 | — | — | 1 | 7.39 |
| CHEMBL122812 | — | — | 2 | 6.28 |
| CHEMBL123291 | — | — | 1 | 6.21 |
| CHEMBL123037 | — | — | 1 | 6.19 |
| CHEMBL122324 | — | — | 1 | 6.04 |
| CHEMBL122149 | — | — | 1 | 5.91 |
| CHEMBL122318 | — | — | 1 | 5.90 |
| CHEMBL122561 | — | — | 1 | 5.89 |
| CHEMBL126152 | — | — | 1 | 5.87 |
| CHEMBL333987 | — | — | 1 | 5.86 |
| CHEMBL123038 | — | — | 1 | 5.85 |
| CHEMBL333413 | — | — | 1 | 5.85 |
| CHEMBL122764 | — | — | 1 | 5.80 |
| CHEMBL123227 | — | — | 1 | 5.77 |
| CHEMBL125656 | — | — | 1 | 5.76 |
| CHEMBL184514 | — | — | 1 | 5.70 |
| CHEMBL334074 | — | — | 1 | 5.70 |
| CHEMBL122043 | — | — | 1 | 5.64 |
| CHEMBL123200 | — | — | 1 | 5.63 |
| CHEMBL122672 | — | — | 1 | 5.48 |
| CHEMBL333716 | — | — | 1 | 5.47 |
| CHEMBL2111806 | — | — | 1 | 5.41 |
| CHEMBL123178 | — | — | 1 | 5.18 |
| CHEMBL126210 | — | — | 1 | 5.18 |
| CHEMBL123592 | — | — | 1 | 5.09 |
| CHEMBL123199 | — | — | 1 | 5.08 |
| CHEMBL124159 | — | — | 1 | 5.03 |
| CHEMBL123987 | — | — | 1 | - |
| CHEMBL421457 | — | — | 1 | - |
| CHEMBL331422 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL122513 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL122812 | — | IC50 | = | 521.0 | nM | 6.28 |
| CHEMBL123291 | — | IC50 | = | 609.0 | nM | 6.21 |
| CHEMBL123037 | — | IC50 | = | 652.0 | nM | 6.19 |
| CHEMBL122324 | — | IC50 | = | 922.0 | nM | 6.04 |
| CHEMBL122149 | — | IC50 | = | 1245.0 | nM | 5.91 |
| CHEMBL122318 | — | IC50 | = | 1257.0 | nM | 5.90 |
| CHEMBL122561 | — | IC50 | = | 1298.0 | nM | 5.89 |
| CHEMBL126152 | — | IC50 | = | 1365.0 | nM | 5.87 |
| CHEMBL333987 | — | IC50 | = | 1373.0 | nM | 5.86 |
| CHEMBL333413 | — | IC50 | = | 1427.0 | nM | 5.85 |
| CHEMBL123038 | — | IC50 | = | 1421.0 | nM | 5.85 |
| CHEMBL122764 | — | IC50 | = | 1578.0 | nM | 5.80 |
| CHEMBL123227 | — | IC50 | = | 1695.0 | nM | 5.77 |
| CHEMBL125656 | — | IC50 | = | 1748.0 | nM | 5.76 |
| CHEMBL184514 | — | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL334074 | — | IC50 | = | 1991.0 | nM | 5.70 |
| CHEMBL122043 | — | IC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL123200 | — | IC50 | = | 2364.0 | nM | 5.63 |
| CHEMBL122672 | — | IC50 | = | 3343.0 | nM | 5.48 |
| CHEMBL333716 | — | IC50 | = | 3368.0 | nM | 5.47 |
| CHEMBL2111806 | — | IC50 | = | 3931.0 | nM | 5.41 |
| CHEMBL126210 | — | IC50 | = | 6597.0 | nM | 5.18 |
| CHEMBL123178 | — | IC50 | = | 6623.0 | nM | 5.18 |
| CHEMBL123592 | — | IC50 | = | 8039.0 | nM | 5.09 |
| CHEMBL123199 | — | IC50 | = | 8340.0 | nM | 5.08 |
| CHEMBL124159 | — | IC50 | = | 9422.0 | nM | 5.03 |
| CHEMBL122350 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL123754 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL121807 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL122424 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL121801 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL122879 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL332776 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL122431 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL331422 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL123987 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL421457 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL122812 | — | IC50 | > | 10000.0 | nM | - |