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Assay Detail

CHEMBL885179

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro anti-HIV activity against HIV-1RF infected in CEM-SS cells using MTS cytoprotection assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Cell Type CEM-SS
Confidence 1 — Organism
Curated By Expert

Target

Human immunodeficiency virus 1 (CHEMBL378)
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Synthesis, anti-HIV activity, and metabolic stability of new alkenyldiarylmethane HIV-1 non-nucleoside reverse transcriptase inhibitors.
Deng BL, Hartman TL, Buckheit RW, Pannecouque C, De Clercq E, Fanwick PE, Cushman M.
J Med Chem (2005) 48 : 6140 -6155
PubMed 16162014 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 20 5.82 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL131761 1 7.70
CHEMBL105859 1 6.68
CHEMBL194923 1 5.16
CHEMBL198425 1 5.15
CHEMBL194649 1 5.14
CHEMBL198276 1 5.08
CHEMBL198551 1 -
CHEMBL2096827 1 -
CHEMBL196121 1 -
CHEMBL196174 1 -
CHEMBL194615 1 -
CHEMBL194617 1 -
CHEMBL381449 1 -
CHEMBL196011 1 -
CHEMBL194957 1 -
CHEMBL198050 1 -
CHEMBL372175 1 -
CHEMBL198201 1 -
CHEMBL196274 1 -
CHEMBL196275 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL131761 EC50 = 20.0 nM 7.70
CHEMBL105859 EC50 = 210.0 nM 6.68
CHEMBL194923 EC50 = 7000.0 nM 5.16
CHEMBL198425 EC50 = 7100.0 nM 5.15
CHEMBL194649 EC50 = 7300.0 nM 5.14
CHEMBL198276 EC50 = 8300.0 nM 5.08
CHEMBL198551 EC50 > 100000.0 nM -
CHEMBL2096827 EC50 > 100000.0 nM -
CHEMBL196121 EC50 > 100000.0 nM -
CHEMBL196174 EC50 > 100000.0 nM -
CHEMBL194615 EC50 > 100000.0 nM -
CHEMBL194617 EC50 > 100000.0 nM -
CHEMBL381449 EC50 > 5000.0 nM -
CHEMBL196011 EC50 > 100000.0 nM -
CHEMBL194957 EC50 > 100000.0 nM -
CHEMBL198050 EC50 > 100000.0 nM -
CHEMBL372175 EC50 > 100000.0 nM -
CHEMBL198201 EC50 > 100000.0 nM -
CHEMBL196274 EC50 > 100000.0 nM -
CHEMBL196275 EC50 > 100000.0 nM -