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Assay Detail

CHEMBL885181

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Effective concentration required to reduce HIV-1-induced cytopathic effect in MT-4 cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Cell Type MT4
Confidence 1 — Organism
Curated By Expert

Target

Human immunodeficiency virus 1 (CHEMBL378)
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Pharmacophore-based design of HIV-1 integrase strand-transfer inhibitors.
Barreca ML, Ferro S, Rao A, De Luca L, Zappalà M, Monforte AM, Debyser Z, Witvrouw M, Chimirri A.
J Med Chem (2005) 48 : 7084 -7088
PubMed 16250669 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 13 5.42 8.33

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL414850 1 8.33
CHEMBL363170 1 5.56
CHEMBL365604 1 5.47
CHEMBL197001 1 5.35
CHEMBL194735 1 5.32
CHEMBL198001 1 5.28
CHEMBL196689 1 5.27
CHEMBL196391 1 5.24
CHEMBL194241 1 5.22
CHEMBL197554 1 5.03
CHEMBL362916 1 4.84
CHEMBL372325 1 4.84
CHEMBL186820 1 4.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL414850 EC50 = 4.7 nM 8.33
CHEMBL363170 EC50 = 2780.0 nM 5.56
CHEMBL365604 EC50 = 3420.0 nM 5.47
CHEMBL197001 EC50 = 4500.0 nM 5.35
CHEMBL194735 EC50 = 4780.0 nM 5.32
CHEMBL198001 EC50 = 5310.0 nM 5.28
CHEMBL196689 EC50 = 5320.0 nM 5.27
CHEMBL196391 EC50 = 5810.0 nM 5.24
CHEMBL194241 EC50 = 6070.0 nM 5.22
CHEMBL197554 EC50 = 9250.0 nM 5.03
CHEMBL362916 EC50 = 14300.0 nM 4.84
CHEMBL372325 EC50 = 14340.0 nM 4.84
CHEMBL186820 EC50 = 19920.0 nM 4.70