Assay Detail
Functional
CHEMBL885329
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity of compound against TLAV (dual) virus that utilizes both CXR4 and CCR5 co-receptor virus was determined
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | tlav virus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery of 4-benzoyl-1-[(4-methoxy-1H- pyrrolo[2,3-b]pyridin-3-yl)oxoacetyl]-2- (R)-methylpiperazine (BMS-378806): a novel HIV-1 attachment inhibitor that interferes with CD4-gp120 interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.92 | 9.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL337301 | — | — | 1 | 9.07 |
| CHEMBL135339 | — | — | 1 | 7.87 |
| CHEMBL336293 | — | — | 1 | 6.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL337301 | — | EC50 | = | 0.85 | nM | 9.07 |
| CHEMBL135339 | — | EC50 | = | 13.6 | nM | 7.87 |
| CHEMBL336293 | — | EC50 | = | 149.0 | nM | 6.83 |