Assay Detail
Binding
CHEMBL885330
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Effective concentration binding towards TRalpha in E25B2 cells (agonistic activity)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | E25B2 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of a novel series of 6-azauracil-based thyroid hormone receptor ligands: potent, TR beta subtype-selective thyromimetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.48 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1544 | LIOTHYRONINE | 4.0 | 1 | 8.70 |
| CHEMBL124205 | — | — | 1 | 7.92 |
| CHEMBL125946 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1544 | LIOTHYRONINE | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL124205 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL125946 | — | EC50 | = | 1500.0 | nM | 5.82 |