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Assay Detail

CHEMBL885336

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Compound was evaluated for the accumulation of cyclic AMP in UMR10606 (rat osteosarcoma) cells.
15
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Cell Type UMR106-06
Confidence 1 — Organism
Curated By Intermediate

Target

UMR106-06 (CHEMBL613502)
Type CELL-LINE
Organism Rattus norvegicus

Publication

Dipeptide mimetics can substitute for the receptor activation domain resulting in highly potent analogues of hPTH(136)
Waelchli R, Gamse R, Bauer W, Lier E, Feyen JH
Bioorg Med Chem Lett (1996) 6 : 1151 -1156
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 15 8.22 9.19

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL276472 1 9.19
CHEMBL2370337 2 9.00
CHEMBL438942 1 8.92
CHEMBL439458 1 8.80
CHEMBL440239 1 8.59
CHEMBL2370336 1 8.48
CHEMBL414363 1 8.36
CHEMBL412178 1 8.31
CHEMBL424859 1 8.30
CHEMBL428635 1 7.89
CHEMBL428849 1 7.82
CHEMBL437658 1 7.58
CHEMBL414103 1 7.52
CHEMBL427924 1 6.02

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL276472 EC50 = 0.65 nM 9.19
CHEMBL2370337 EC50 = 1.0 nM 9.00
CHEMBL438942 EC50 = 1.2 nM 8.92
CHEMBL439458 EC50 = 1.6 nM 8.80
CHEMBL440239 EC50 = 2.6 nM 8.59
CHEMBL2370336 EC50 = 3.3 nM 8.48
CHEMBL2370337 EC50 = 3.3 nM 8.48
CHEMBL414363 EC50 = 4.4 nM 8.36
CHEMBL412178 EC50 = 4.9 nM 8.31
CHEMBL424859 EC50 = 5.0 nM 8.30
CHEMBL428635 EC50 = 13.0 nM 7.89
CHEMBL428849 EC50 = 15.0 nM 7.82
CHEMBL437658 EC50 = 26.0 nM 7.58
CHEMBL414103 EC50 = 30.0 nM 7.52
CHEMBL427924 EC50 = 958.0 nM 6.02