Assay Detail
Binding
CHEMBL885381
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Low binding affinity towards human dopamine receptor 3 expressed in Chinese hamster ovary cells using [3H]spiperone (0.5 nM) as radioligand
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | ovary |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Pharmacophore-guided drug discovery investigations leading to bioactive 5-aminotetrahydropyrazolopyridines. Implications for the binding mode of heterocyclic dopamine D3 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.82 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301265 | PRAMIPEXOLE | 4.0 | 1 | 7.42 |
| CHEMBL193337 | — | — | 1 | 6.96 |
| CHEMBL316983 | — | — | 1 | 6.82 |
| CHEMBL196928 | — | — | 1 | 6.70 |
| CHEMBL194099 | — | — | 1 | 6.64 |
| CHEMBL240773 | QUINPIROLE | 2.0 | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301265 | PRAMIPEXOLE | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL193337 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL316983 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL196928 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL194099 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL240773 | QUINPIROLE | Ki | = | 420.0 | nM | 6.38 |