Assay Detail
Binding
CHEMBL885385
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Displacement of [3H]rauwolscine from rat brain Alpha-2 adrenergic receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
WB 4101-related compounds. 2. Role of the ethylene chain separating amine and phenoxy units on the affinity for alpha(1)-adrenoreceptor subtypes and 5-HT(1A) receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.37 | 7.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25554 | — | — | 1 | 7.83 |
| CHEMBL134428 | — | — | 1 | 6.27 |
| CHEMBL135974 | — | — | 1 | 6.23 |
| CHEMBL132378 | — | — | 1 | 6.21 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 6.08 |
| CHEMBL135973 | — | — | 1 | 6.05 |
| CHEMBL13647 | BMY-7378 | — | 1 | 5.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25554 | — | Ki | = | 14.79 | nM | 7.83 |
| CHEMBL134428 | — | Ki | = | 537.03 | nM | 6.27 |
| CHEMBL135974 | — | Ki | = | 588.84 | nM | 6.23 |
| CHEMBL132378 | — | Ki | = | 616.6 | nM | 6.21 |
| CHEMBL56 | 8-OH-DPAT | Ki | = | 831.76 | nM | 6.08 |
| CHEMBL135973 | — | Ki | = | 891.25 | nM | 6.05 |
| CHEMBL13647 | BMY-7378 | Ki | = | 1174.9 | nM | 5.93 |