Assay Detail
Binding
CHEMBL885387
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Evaluated for the binding affinity towards vasopressin (V2) receptor in rat kidney membrane using [3H]AVP as radioligand
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Kidney |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
N-Methylbenzanilide derivatives as a novel class of selective V(1A) receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.76 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307483 | — | — | 1 | 8.92 |
| CHEMBL310921 | — | — | 1 | 7.47 |
| CHEMBL306718 | — | — | 1 | 7.38 |
| CHEMBL74593 | — | — | 1 | 7.13 |
| CHEMBL77105 | — | — | 1 | 7.03 |
| CHEMBL1794053 | GW407323A | — | 1 | 6.78 |
| CHEMBL75489 | — | — | 1 | 6.35 |
| CHEMBL307269 | — | — | 1 | 6.11 |
| CHEMBL76498 | — | — | 1 | 5.87 |
| CHEMBL307487 | — | — | 1 | 5.69 |
| CHEMBL76763 | — | — | 1 | 5.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307483 | — | Ki | = | 1.19 | nM | 8.92 |
| CHEMBL310921 | — | Ki | = | 33.9 | nM | 7.47 |
| CHEMBL306718 | — | Ki | = | 41.5 | nM | 7.38 |
| CHEMBL74593 | — | Ki | = | 73.4 | nM | 7.13 |
| CHEMBL77105 | — | Ki | = | 94.5 | nM | 7.03 |
| CHEMBL1794053 | GW407323A | Ki | = | 168.0 | nM | 6.78 |
| CHEMBL75489 | — | Ki | = | 445.0 | nM | 6.35 |
| CHEMBL307269 | — | Ki | = | 782.0 | nM | 6.11 |
| CHEMBL76498 | — | Ki | = | 1360.0 | nM | 5.87 |
| CHEMBL307487 | — | Ki | = | 2040.0 | nM | 5.69 |
| CHEMBL76763 | — | Ki | = | 2250.0 | nM | 5.65 |