Assay Detail
Binding
CHEMBL885433
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Binding affinity at human histamine H3 receptor
30
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Novel tetrahydroisoquinolines are histamine H3 antagonists and serotonin reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 30 | 8.06 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL397299 | — | — | 1 | 8.70 |
| CHEMBL395608 | — | — | 1 | 8.70 |
| CHEMBL394861 | — | — | 1 | 8.70 |
| CHEMBL233054 | — | — | 3 | 8.70 |
| CHEMBL397300 | — | — | 1 | 8.52 |
| CHEMBL397065 | — | — | 1 | 8.48 |
| CHEMBL246748 | — | — | 1 | 8.46 |
| CHEMBL233053 | — | — | 1 | 8.42 |
| CHEMBL395609 | — | — | 1 | 8.25 |
| CHEMBL246333 | — | — | 1 | 8.25 |
| CHEMBL395368 | — | — | 3 | 8.19 |
| CHEMBL247161 | — | — | 1 | 8.16 |
| CHEMBL246127 | — | — | 1 | 8.14 |
| CHEMBL246749 | — | — | 1 | 8.08 |
| CHEMBL246332 | — | — | 1 | 8.08 |
| CHEMBL246541 | — | — | 1 | 8.03 |
| CHEMBL246331 | — | — | 1 | 8.01 |
| CHEMBL246954 | — | — | 1 | 8.00 |
| CHEMBL246955 | — | — | 3 | 8.00 |
| CHEMBL246747 | — | — | 1 | 7.96 |
| CHEMBL246542 | — | — | 1 | 7.75 |
| CHEMBL246540 | — | — | 1 | 7.51 |
| CHEMBL246953 | — | — | 1 | 7.34 |
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL394861 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL397299 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL395608 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL233054 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL397300 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL397065 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL246748 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL233054 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL233053 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL233054 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL395609 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL246333 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL395368 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL247161 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL246127 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL246749 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL246332 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL246541 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL246331 | — | Ki | = | 9.7 | nM | 8.01 |
| CHEMBL246954 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL246955 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL246955 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL246747 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL246955 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL395368 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL395368 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL246542 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL246540 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL246953 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL41 | FLUOXETINE | Ki | = | 7300.0 | nM | 5.14 |