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Assay Detail

CHEMBL885805

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Binding
Inhibition of human factor 10a
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Coagulation factor X (CHEMBL244)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Pyrazole-based factor Xa inhibitors containing N-arylpiperidinyl P4 residues.
Qiao JX, Cheng X, Smallheer JM, Galemmo RA, Drummond S, Pinto DJ, Cheney DL, He K, Wong PC, Luettgen JM, Knabb RM, Wexler RR, Lam PY.
Bioorg Med Chem Lett (2007) 17 : 1432 -1437
PubMed 17174550 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 26 8.52 9.59

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL247756 1 9.59
CHEMBL247192 1 9.59
CHEMBL176140 1 9.52
CHEMBL392460 1 9.46
CHEMBL247191 1 9.39
CHEMBL397049 1 9.24
CHEMBL246738 1 9.21
CHEMBL397124 1 9.17
CHEMBL246945 1 9.15
CHEMBL395823 1 9.14
CHEMBL247561 1 9.06
CHEMBL396640 1 9.00
CHEMBL428749 1 8.77
CHEMBL246946 1 8.62
CHEMBL396122 1 8.52
CHEMBL397298 1 8.41
CHEMBL395195 1 8.31
CHEMBL246323 1 8.24
CHEMBL397310 1 8.18
CHEMBL246948 1 8.06
CHEMBL395196 1 7.85
CHEMBL394039 1 7.64
CHEMBL395366 1 7.54
CHEMBL246742 1 7.09
CHEMBL246737 1 7.04
CHEMBL396123 1 5.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL247756 Ki = 0.26 nM 9.59
CHEMBL247192 Ki = 0.26 nM 9.59
CHEMBL176140 Ki = 0.3 nM 9.52
CHEMBL392460 Ki = 0.35 nM 9.46
CHEMBL247191 Ki = 0.41 nM 9.39
CHEMBL397049 Ki = 0.57 nM 9.24
CHEMBL246738 Ki = 0.61 nM 9.21
CHEMBL397124 Ki = 0.67 nM 9.17
CHEMBL246945 Ki = 0.7 nM 9.15
CHEMBL395823 Ki = 0.73 nM 9.14
CHEMBL247561 Ki = 0.87 nM 9.06
CHEMBL396640 Ki = 1.0 nM 9.00
CHEMBL428749 Ki = 1.7 nM 8.77
CHEMBL246946 Ki = 2.4 nM 8.62
CHEMBL396122 Ki = 3.0 nM 8.52
CHEMBL397298 Ki = 3.9 nM 8.41
CHEMBL395195 Ki = 4.9 nM 8.31
CHEMBL246323 Ki = 5.7 nM 8.24
CHEMBL397310 Ki = 6.6 nM 8.18
CHEMBL246948 Ki = 8.8 nM 8.06
CHEMBL395196 Ki = 14.0 nM 7.85
CHEMBL394039 Ki = 23.0 nM 7.64
CHEMBL395366 Ki = 29.0 nM 7.54
CHEMBL246742 Ki = 81.0 nM 7.09
CHEMBL246737 Ki = 92.0 nM 7.04
CHEMBL396123 Ki = 2000.0 nM 5.70