Assay Detail
Binding
CHEMBL885870
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Inhibition of porcine TACE
22
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Disintegrin and metalloproteinase domain-containing protein 17 (CHEMBL3332) ↗| Type | SINGLE PROTEIN |
| Organism | Sus scrofa |
Publication
Discovery of novel hydantoins as selective non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.92 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL246577 | — | — | 2 | 7.96 |
| CHEMBL245581 | — | — | 1 | 7.89 |
| CHEMBL245384 | — | — | 1 | 7.62 |
| CHEMBL429107 | — | — | 1 | 7.62 |
| CHEMBL245582 | — | — | 1 | 7.60 |
| CHEMBL442421 | — | — | 1 | 7.55 |
| CHEMBL229070 | — | — | 1 | 7.54 |
| CHEMBL245383 | — | — | 1 | 7.27 |
| CHEMBL246376 | — | — | 1 | 7.19 |
| CHEMBL392172 | — | — | 1 | 7.01 |
| CHEMBL393863 | — | — | 1 | 6.82 |
| CHEMBL246563 | — | — | 1 | 6.77 |
| CHEMBL245774 | — | — | 1 | 6.68 |
| CHEMBL393444 | — | — | 1 | 6.64 |
| CHEMBL245382 | — | — | 1 | 6.57 |
| CHEMBL393445 | — | — | 1 | 6.05 |
| CHEMBL245776 | — | — | 1 | 5.43 |
| CHEMBL391362 | — | — | 1 | 5.26 |
| CHEMBL246576 | — | — | 1 | 5.13 |
| CHEMBL246171 | — | — | 1 | - |
| CHEMBL245974 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL246577 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL245581 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL246577 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL245384 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL429107 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL245582 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL442421 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL229070 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL245383 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL246376 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL392172 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL393863 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL246563 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL245774 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL393444 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL245382 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL393445 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL245776 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL391362 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL246576 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL246171 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL245974 | — | IC50 | > | 100000.0 | nM | - |