Assay Detail
Binding
CHEMBL885886
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Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Dopamine/serotonin receptor ligands. Part 15: Oxygenation of the benz-indolo-azecine LE 300 leads to novel subnanomolar dopamine D1/D5 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.58 | 9.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL201170 | — | — | 1 | 9.41 |
| CHEMBL245570 | — | — | 1 | 9.25 |
| CHEMBL396560 | — | — | 1 | 9.09 |
| CHEMBL441618 | — | — | 1 | 8.72 |
| CHEMBL245764 | — | — | 1 | 8.70 |
| CHEMBL245571 | — | — | 1 | 8.43 |
| CHEMBL201525 | — | — | 1 | 8.35 |
| CHEMBL396561 | — | — | 1 | 7.72 |
| CHEMBL380330 | — | — | 1 | 7.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL201170 | — | Ki | = | 0.39 | nM | 9.41 |
| CHEMBL245570 | — | Ki | = | 0.56 | nM | 9.25 |
| CHEMBL396560 | — | Ki | = | 0.82 | nM | 9.09 |
| CHEMBL441618 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL245764 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL245571 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL201525 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL396561 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL380330 | — | Ki | = | 28.5 | nM | 7.54 |