Assay Detail
Functional
CHEMBL885901
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Inhibition of VEGFR2 by cell-based assay
74
Total Activities
74
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
ortho-Substituted azoles as selective and dual inhibitors of VEGF receptors 1 and 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 74 | 6.62 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL101253 | VATALANIB | 3.0 | 1 | 7.68 |
| CHEMBL401041 | — | — | 1 | 7.35 |
| CHEMBL202011 | — | — | 1 | 7.30 |
| CHEMBL238529 | — | — | 1 | 7.24 |
| CHEMBL393779 | — | — | 1 | 7.19 |
| CHEMBL238737 | — | — | 1 | 7.19 |
| CHEMBL401040 | — | — | 1 | 7.19 |
| CHEMBL241314 | — | — | 1 | 7.16 |
| CHEMBL238522 | — | — | 1 | 7.12 |
| CHEMBL241265 | — | — | 1 | 7.10 |
| CHEMBL391127 | — | — | 1 | 7.09 |
| CHEMBL394020 | — | — | 1 | 7.06 |
| CHEMBL240643 | — | — | 1 | 7.06 |
| CHEMBL394204 | — | — | 1 | 7.05 |
| CHEMBL153843 | — | — | 1 | 7.05 |
| CHEMBL241084 | — | — | 1 | 7.04 |
| CHEMBL238528 | — | — | 1 | 7.02 |
| CHEMBL400216 | — | — | 1 | 6.99 |
| CHEMBL429643 | — | — | 1 | 6.96 |
| CHEMBL392987 | — | — | 1 | 6.96 |
| CHEMBL238530 | — | — | 1 | 6.96 |
| CHEMBL240209 | — | — | 1 | 6.89 |
| CHEMBL240455 | — | — | 1 | 6.89 |
| CHEMBL394203 | — | — | 1 | 6.82 |
| CHEMBL238735 | — | — | 1 | 6.77 |
| CHEMBL392513 | — | — | 1 | 6.75 |
| CHEMBL241313 | — | — | 1 | 6.68 |
| CHEMBL238719 | — | — | 1 | 6.68 |
| CHEMBL393963 | — | — | 1 | 6.50 |
| CHEMBL241669 | — | — | 1 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL101253 | VATALANIB | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL401041 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL202011 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL238529 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL393779 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL238737 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL401040 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL241314 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL238522 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL241265 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL391127 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL394020 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL240643 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL153843 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL394204 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL241084 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL238528 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL400216 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL429643 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL392987 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL238530 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL240209 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL240455 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL394203 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL238735 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL392513 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL238719 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL241313 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL393963 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL241669 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL238720 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL240456 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL241667 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL240818 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL393418 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL238526 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL429455 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL240607 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL240642 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL393924 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL392789 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL238531 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL24828 | VANDETANIB | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL238521 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL241492 | — | IC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL240406 | — | IC50 | = | 3540.0 | nM | 5.45 |
| CHEMBL241668 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL238940 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL392964 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL238939 | — | IC50 | > | 10000.0 | nM | - |