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Assay Detail

CHEMBL886095

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Functional
Antagonist activity at human histamine H3 receptor
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Histamine H3 receptor (CHEMBL264)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and biological evaluation of diamine-based histamine H3 antagonists with serotonin reuptake inhibitor activity.
Stocking EM, Miller JM, Barbier AJ, Wilson SJ, Boggs JD, McAllister HM, Wu J, Lovenberg TW, Carruthers NI, Wolin RL.
Bioorg Med Chem Lett (2007) 17 : 3130 -3135
PubMed 17412583 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 1 9.30 9.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL438490 1 9.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL438490 Kd = 0.5012 nM 9.30