Assay Detail
Functional
CHEMBL886676
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 in C8166 cells assessed as inhibition of syncytia formation
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | C8166 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and anti-HIV-1 activities of novel podophyllotoxin derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.38 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 8.54 |
| CHEMBL245888 | — | — | 1 | 8.05 |
| CHEMBL394946 | — | — | 1 | 6.77 |
| CHEMBL247522 | — | — | 1 | 6.62 |
| CHEMBL394945 | — | — | 1 | 6.54 |
| CHEMBL247735 | — | — | 1 | 5.98 |
| CHEMBL247523 | — | — | 1 | 5.36 |
| CHEMBL437756 | — | — | 1 | 5.26 |
| CHEMBL443313 | — | — | 1 | 4.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | EC50 | = | 2.9 | nM | 8.54 |
| CHEMBL245888 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL394946 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL247522 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL394945 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL247735 | — | EC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL247523 | — | EC50 | = | 4390.0 | nM | 5.36 |
| CHEMBL437756 | — | EC50 | = | 5460.0 | nM | 5.26 |
| CHEMBL443313 | — | EC50 | = | 46900.0 | nM | 4.33 |