Assay Detail
Binding
CHEMBL886679
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of DPP4 in rat plasma by fluorescence assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
[(S)-gamma-(4-Aryl-1-piperazinyl)-l-prolyl]thiazolidines as a novel series of highly potent and long-lasting DPP-IV inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 8.08 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL399610 | — | — | 1 | 8.96 |
| CHEMBL241464 | — | — | 1 | 8.92 |
| CHEMBL241253 | — | — | 1 | 8.85 |
| CHEMBL241252 | — | — | 1 | 8.74 |
| CHEMBL238515 | — | — | 1 | 8.74 |
| CHEMBL399405 | — | — | 1 | 8.72 |
| CHEMBL391466 | — | — | 1 | 8.66 |
| CHEMBL239356 | — | — | 1 | 8.54 |
| CHEMBL239565 | — | — | 1 | 8.51 |
| CHEMBL238516 | — | — | 1 | 8.48 |
| CHEMBL395854 | — | — | 1 | 8.46 |
| CHEMBL239564 | — | — | 1 | 8.41 |
| CHEMBL241246 | — | — | 1 | 8.38 |
| CHEMBL391578 | — | — | 1 | 8.33 |
| CHEMBL391577 | — | — | 1 | 8.14 |
| CHEMBL241245 | — | — | 1 | 8.14 |
| CHEMBL239984 | — | — | 1 | 8.05 |
| CHEMBL395606 | — | — | 1 | 8.02 |
| CHEMBL238507 | — | — | 1 | 7.99 |
| CHEMBL239983 | — | — | 1 | 7.96 |
| CHEMBL238506 | — | — | 1 | 7.77 |
| CHEMBL397893 | — | — | 1 | 7.76 |
| CHEMBL240601 | — | — | 1 | 7.75 |
| CHEMBL241674 | — | — | 1 | 7.72 |
| CHEMBL240602 | — | — | 1 | 7.50 |
| CHEMBL391433 | — | — | 1 | 7.42 |
| CHEMBL391331 | — | — | 1 | 7.13 |
| CHEMBL391332 | — | — | 1 | 7.09 |
| CHEMBL241673 | — | — | 1 | 6.92 |
| CHEMBL224435 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL399610 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL241464 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL241253 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL241252 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL238515 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL399405 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL391466 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL239356 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL239565 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL238516 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL395854 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL239564 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL241246 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL391578 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL391577 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL241245 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL239984 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL395606 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL238507 | — | IC50 | = | 10.3 | nM | 7.99 |
| CHEMBL239983 | — | IC50 | = | 10.9 | nM | 7.96 |
| CHEMBL238506 | — | IC50 | = | 16.9 | nM | 7.77 |
| CHEMBL397893 | — | IC50 | = | 17.5 | nM | 7.76 |
| CHEMBL240601 | — | IC50 | = | 17.6 | nM | 7.75 |
| CHEMBL241674 | — | IC50 | = | 18.9 | nM | 7.72 |
| CHEMBL240602 | — | IC50 | = | 31.4 | nM | 7.50 |
| CHEMBL391433 | — | IC50 | = | 38.3 | nM | 7.42 |
| CHEMBL391331 | — | IC50 | = | 74.4 | nM | 7.13 |
| CHEMBL391332 | — | IC50 | = | 81.1 | nM | 7.09 |
| CHEMBL241673 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL224435 | — | IC50 | = | 607.0 | nM | 6.22 |