Assay Detail
Functional
CHEMBL886683
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Antiviral activity against HIV1 3B in MT2 cells assessed as inhibition of viral-mediated T-cell death by MTT method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
[d4U]-butyne-[HI-236] as a non-cleavable, bifunctional NRTI/NNRTI HIV-1 reverse-transcriptase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.83 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL240417 | — | — | 1 | 7.64 |
| CHEMBL240416 | — | — | 1 | 7.38 |
| CHEMBL398987 | — | — | 1 | 6.60 |
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL240417 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL240416 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL398987 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL991 | STAVUDINE | EC50 | = | 2000.0 | nM | 5.70 |