Assay Detail
Functional
CHEMBL886722
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Inhibition of TNFalpha production in UVB irradiated human HaCaT cells administered 2 hrs before irradiation by fluoroimmunoassay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HaCaT |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of diverse thio avarol derivatives as potential UVB photoprotective candidates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.46 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54909 | FRAXETIN | — | 1 | 5.55 |
| CHEMBL238756 | — | — | 1 | 5.48 |
| CHEMBL239818 | — | — | 1 | 5.43 |
| CHEMBL401450 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54909 | FRAXETIN | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL238756 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL239818 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL401450 | — | IC50 | = | 4200.0 | nM | 5.38 |