Assay Detail
Binding
CHEMBL887076
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Inhibition of Tie2 after 90 mins by HTRF assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Synthesis, structural analysis, and SAR studies of triazine derivatives as potent, selective Tie-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 8.27 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL245744 | — | — | 1 | 9.00 |
| CHEMBL245746 | — | — | 1 | 9.00 |
| CHEMBL245947 | — | — | 1 | 9.00 |
| CHEMBL221484 | — | — | 1 | 9.00 |
| CHEMBL394693 | — | — | 1 | 8.70 |
| CHEMBL245745 | — | — | 1 | 8.52 |
| CHEMBL246150 | — | — | 1 | 8.40 |
| CHEMBL394694 | — | — | 1 | 8.40 |
| CHEMBL245948 | — | — | 1 | 8.22 |
| CHEMBL246151 | — | — | 1 | 8.22 |
| CHEMBL246152 | — | — | 1 | 8.10 |
| CHEMBL397090 | — | — | 1 | 8.05 |
| CHEMBL394692 | — | — | 1 | 7.89 |
| CHEMBL246356 | — | — | 1 | 7.80 |
| CHEMBL246355 | — | — | 1 | 7.77 |
| CHEMBL245549 | — | — | 1 | 7.77 |
| CHEMBL397089 | — | — | 1 | 7.70 |
| CHEMBL245949 | — | — | 1 | 7.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL245744 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL245746 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL245947 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL221484 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL394693 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL245745 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL246150 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL394694 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL245948 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL246151 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL246152 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL397090 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL394692 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL246356 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL246355 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL245549 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL397089 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL245949 | — | IC50 | = | 55.0 | nM | 7.26 |