Assay Detail
Functional
CHEMBL887174
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3B in CEM cells assessed as inhibition of viral-induced cytopathicity
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Newer tetracycline derivatives: synthesis, anti-HIV, antimycobacterial activities and inhibition of HIV-1 integrase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 4.96 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL239177 | — | — | 1 | 5.28 |
| CHEMBL396686 | — | — | 1 | 5.12 |
| CHEMBL241495 | — | — | 1 | 5.08 |
| CHEMBL396688 | — | — | 1 | 4.91 |
| CHEMBL396907 | — | — | 1 | 4.84 |
| CHEMBL241293 | — | — | 1 | 4.82 |
| CHEMBL396687 | — | — | 1 | 4.70 |
| CHEMBL239176 | — | — | 1 | - |
| CHEMBL561 | LOMEFLOXACIN | 4.0 | 1 | - |
| CHEMBL1434 | MINOCYCLINE | 4.0 | 1 | - |
| CHEMBL1237046 | ROLITETRACYCLINE | 2.0 | 1 | - |
| CHEMBL1440 | TETRACYCLINE | 4.0 | 1 | - |
| CHEMBL239813 | — | — | 1 | - |
| CHEMBL392612 | — | — | 1 | - |
| CHEMBL392611 | — | — | 1 | - |
| CHEMBL392565 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL239177 | — | EC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL396686 | — | EC50 | = | 7580.0 | nM | 5.12 |
| CHEMBL241495 | — | EC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL396688 | — | EC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL396907 | — | EC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL241293 | — | EC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL396687 | — | EC50 | = | 20200.0 | nM | 4.70 |
| CHEMBL239176 | — | EC50 | > | 17700.0 | nM | - |
| CHEMBL561 | LOMEFLOXACIN | EC50 | - | — | - | |
| CHEMBL1434 | MINOCYCLINE | EC50 | > | 52100.0 | nM | - |
| CHEMBL1237046 | ROLITETRACYCLINE | EC50 | > | 45500.0 | nM | - |
| CHEMBL1440 | TETRACYCLINE | EC50 | > | 40500.0 | nM | - |
| CHEMBL239813 | — | EC50 | > | 126000.0 | nM | - |
| CHEMBL392612 | — | EC50 | > | 120000.0 | nM | - |
| CHEMBL392611 | — | EC50 | > | 130100.0 | nM | - |
| CHEMBL392565 | — | EC50 | > | 28900.0 | nM | - |