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Assay Detail

CHEMBL887250

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Functional
Antiparasitic activity against Plasmodium falciparum K1
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Intermediate

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Synthesis and antiparasitic evaluation of bis-2,5-[4-guanidinophenyl]thiophenes.
Gonzalez JL, Stephens CE, Wenzler T, Brun R, Tanious FA, Wilson WD, Barszcz T, Werbovetz KA, Boykin DW.
Eur J Med Chem (2007) 42 : 552 -557
PubMed 17178177 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 7.26 8.44

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL231082 1 8.44
CHEMBL24057 FURAMIDINE -1.0 1 7.81
CHEMBL397654 1 7.64
CHEMBL228368 1 7.37
CHEMBL55 PENTAMIDINE 4.0 1 7.23
CHEMBL231285 1 6.97
CHEMBL231385 1 6.87
CHEMBL228637 1 6.81
CHEMBL231386 1 6.80
CHEMBL76 CHLOROQUINE 4.0 1 6.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL231082 IC50 = 3.6 nM 8.44
CHEMBL24057 FURAMIDINE IC50 = 15.5 nM 7.81
CHEMBL397654 IC50 = 23.0 nM 7.64
CHEMBL228368 IC50 = 42.7 nM 7.37
CHEMBL55 PENTAMIDINE IC50 = 58.4 nM 7.23
CHEMBL231285 IC50 = 107.0 nM 6.97
CHEMBL231385 IC50 = 134.0 nM 6.87
CHEMBL228637 IC50 = 154.0 nM 6.81
CHEMBL231386 IC50 = 160.0 nM 6.80
CHEMBL76 CHLOROQUINE IC50 = 201.0 nM 6.70