Assay Detail
Functional
CHEMBL887284
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human beta-3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and evaluation of potent and selective beta3 adrenergic receptor agonists containing heterobiaryl carboxylic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 8.68 | 10.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL245873 | — | — | 1 | 10.20 |
| CHEMBL245673 | — | — | 1 | 9.60 |
| CHEMBL247520 | — | — | 1 | 9.50 |
| CHEMBL395834 | — | — | 1 | 9.40 |
| CHEMBL247315 | — | — | 1 | 9.10 |
| CHEMBL245875 | — | — | 1 | 8.90 |
| CHEMBL247519 | — | — | 1 | 8.90 |
| CHEMBL247518 | — | — | 1 | 8.80 |
| CHEMBL393470 | — | — | 1 | 8.70 |
| CHEMBL393471 | — | — | 1 | 8.40 |
| CHEMBL430390 | — | — | 1 | 8.20 |
| CHEMBL245874 | — | — | 1 | 8.10 |
| CHEMBL154419 | — | — | 1 | 7.80 |
| CHEMBL393469 | — | — | 1 | 7.80 |
| CHEMBL246908 | — | — | 1 | 7.80 |
| CHEMBL153558 | — | — | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL245873 | — | EC50 | = | 0.0631 | nM | 10.20 |
| CHEMBL245673 | — | EC50 | = | 0.2512 | nM | 9.60 |
| CHEMBL247520 | — | EC50 | = | 0.3162 | nM | 9.50 |
| CHEMBL395834 | — | EC50 | = | 0.3981 | nM | 9.40 |
| CHEMBL247315 | — | EC50 | = | 0.7943 | nM | 9.10 |
| CHEMBL245875 | — | EC50 | = | 1.259 | nM | 8.90 |
| CHEMBL247519 | — | EC50 | = | 1.259 | nM | 8.90 |
| CHEMBL247518 | — | EC50 | = | 1.585 | nM | 8.80 |
| CHEMBL393470 | — | EC50 | = | 1.995 | nM | 8.70 |
| CHEMBL393471 | — | EC50 | = | 3.981 | nM | 8.40 |
| CHEMBL430390 | — | EC50 | = | 6.31 | nM | 8.20 |
| CHEMBL245874 | — | EC50 | = | 7.943 | nM | 8.10 |
| CHEMBL154419 | — | EC50 | = | 15.85 | nM | 7.80 |
| CHEMBL393469 | — | EC50 | = | 15.85 | nM | 7.80 |
| CHEMBL246908 | — | EC50 | = | 15.85 | nM | 7.80 |
| CHEMBL153558 | — | EC50 | = | 25.12 | nM | 7.60 |