Compound Detail
CHEMBL247519
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Basic Information
| ChEMBL ID | CHEMBL247519 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZGXVKSIBYRIOTG-ACJLOTCBSA-N |
3
Targets
3
Activities
1
Assay Types
2
PK Parameters
5
Publications
0
Known Names
Molecular Properties
415.9
MW (Da)
3.82
ALogP
6
HBA
4
HBD
107.6
PSA (Ų)
0.42
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 8.9
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Beta-3 adrenergic receptor CHEMBL246 | EC50 | 8.9 | 8.9 | 1.3 | 1 |
| Beta-1 adrenergic receptor CHEMBL213 | EC50 | 7.6 | 7.6 | 25.1 | 1 |
| Beta-2 adrenergic receptor CHEMBL210 | EC50 | 6.4 | 6.4 | 398.1 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 5.3 | mL.min-1.kg-1 | Canis lupus familiaris |
| T1/2 | 1.0 | hr | Canis lupus familiaris |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Beta-3 adrenergic receptor | EC50 | = | 1.259 | nM | 8.9 | Agonist activity at human beta-3 adrenergic receptor expressed in CHO cells asse... | 17560786 |
| Beta-1 adrenergic receptor | EC50 | = | 25.12 | nM | 7.6 | Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells asse... | 17560786 |
| Beta-2 adrenergic receptor | EC50 | = | 398.11 | nM | 6.4 | Agonist activity at human beta-2 adrenergic receptor expressed in CHO cells asse... | 17560786 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17560786 | 10.1016/j.bmcl.2007.05.069 | Beta-3 adrenergic receptor | 2 |
| 17560786 | 10.1016/j.bmcl.2007.05.069 | Beta-2 adrenergic receptor | 2 |
| 17560786 | 10.1016/j.bmcl.2007.05.069 | Beta-1 adrenergic receptor | 2 |
| 17560786 | 10.1016/j.bmcl.2007.05.069 | Canis familiaris | 2 |
| 17560786 | 10.1016/j.bmcl.2007.05.069 | Unchecked | 2 |
Data from ChEMBL 36 via Core Engine