Assay Detail
Functional
CHEMBL887285
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human beta-2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and evaluation of potent and selective beta3 adrenergic receptor agonists containing heterobiaryl carboxylic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 6.63 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL154419 | — | — | 1 | 7.30 |
| CHEMBL247518 | — | — | 1 | 7.30 |
| CHEMBL430390 | — | — | 1 | 7.30 |
| CHEMBL247520 | — | — | 1 | 7.10 |
| CHEMBL393470 | — | — | 1 | 7.00 |
| CHEMBL246908 | — | — | 1 | 7.00 |
| CHEMBL245673 | — | — | 1 | 6.90 |
| CHEMBL393469 | — | — | 1 | 6.90 |
| CHEMBL247315 | — | — | 1 | 6.80 |
| CHEMBL393471 | — | — | 1 | 6.50 |
| CHEMBL247519 | — | — | 1 | 6.40 |
| CHEMBL153558 | — | — | 1 | 6.40 |
| CHEMBL395834 | — | — | 1 | 6.20 |
| CHEMBL245873 | — | — | 1 | 6.10 |
| CHEMBL245874 | — | — | 1 | 5.60 |
| CHEMBL245875 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL154419 | — | EC50 | = | 50.12 | nM | 7.30 |
| CHEMBL247518 | — | EC50 | = | 50.12 | nM | 7.30 |
| CHEMBL430390 | — | EC50 | = | 50.12 | nM | 7.30 |
| CHEMBL247520 | — | EC50 | = | 79.43 | nM | 7.10 |
| CHEMBL393470 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL246908 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL245673 | — | EC50 | = | 125.89 | nM | 6.90 |
| CHEMBL393469 | — | EC50 | = | 125.89 | nM | 6.90 |
| CHEMBL247315 | — | EC50 | = | 158.49 | nM | 6.80 |
| CHEMBL393471 | — | EC50 | = | 316.23 | nM | 6.50 |
| CHEMBL247519 | — | EC50 | = | 398.11 | nM | 6.40 |
| CHEMBL153558 | — | EC50 | = | 398.11 | nM | 6.40 |
| CHEMBL395834 | — | EC50 | = | 630.96 | nM | 6.20 |
| CHEMBL245873 | — | EC50 | = | 794.33 | nM | 6.10 |
| CHEMBL245874 | — | EC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL245875 | — | EC50 | = | 5011.87 | nM | 5.30 |