Assay Detail
Functional
CHEMBL887304
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Cytotoxicity against HCT116 cells assessed as cell survival by SRB assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and preliminary biological evaluation of a novel triazole analogue of ceramide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 4.84 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL249707 | — | — | 1 | 4.92 |
| CHEMBL249908 | — | — | 1 | 4.90 |
| CHEMBL399044 | — | — | 1 | 4.89 |
| CHEMBL249907 | — | — | 1 | 4.89 |
| CHEMBL249706 | — | — | 1 | 4.86 |
| CHEMBL249704 | — | — | 1 | 4.80 |
| CHEMBL105867 | — | — | 1 | 4.61 |
| CHEMBL249705 | — | — | 1 | - |
| CHEMBL249278 | — | — | 1 | - |
| CHEMBL249910 | — | — | 1 | - |
| CHEMBL398457 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL249707 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL249908 | — | EC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL399044 | — | EC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL249907 | — | EC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL249706 | — | EC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL249704 | — | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL105867 | — | EC50 | = | 24500.0 | nM | 4.61 |
| CHEMBL249705 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL249278 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL249910 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL398457 | — | EC50 | > | 50000.0 | nM | - |