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Assay Detail

CHEMBL887305

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against NCI-H358 cells assessed as cell survival by SRB assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type NCI-H358
Confidence 1 — Organism
Curated By Intermediate

Target

NCI-H358 (CHEMBL614135)
Type CELL-LINE
Organism Homo sapiens

Publication

Design, synthesis, and preliminary biological evaluation of a novel triazole analogue of ceramide.
Kim S, Cho M, Lee T, Lee S, Min HY, Lee SK.
Bioorg Med Chem Lett (2007) 17 : 4584 -4587
PubMed 17561396 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 11 4.84 4.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL399044 1 4.89
CHEMBL249908 1 4.89
CHEMBL249706 1 4.88
CHEMBL249907 1 4.87
CHEMBL249707 1 4.86
CHEMBL249704 1 4.80
CHEMBL105867 1 4.71
CHEMBL249705 1 -
CHEMBL249278 1 -
CHEMBL249910 1 -
CHEMBL398457 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL399044 EC50 = 12900.0 nM 4.89
CHEMBL249908 EC50 = 12800.0 nM 4.89
CHEMBL249706 EC50 = 13200.0 nM 4.88
CHEMBL249907 EC50 = 13600.0 nM 4.87
CHEMBL249707 EC50 = 13700.0 nM 4.86
CHEMBL249704 EC50 = 15700.0 nM 4.80
CHEMBL105867 EC50 = 19600.0 nM 4.71
CHEMBL249705 EC50 > 50000.0 nM -
CHEMBL249278 EC50 > 50000.0 nM -
CHEMBL249910 EC50 > 50000.0 nM -
CHEMBL398457 EC50 > 50000.0 nM -