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Assay Detail

CHEMBL887359

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Functional
Agonist activity at human androgen receptor expressed in CV1 cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CV-1
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Androgen receptor (CHEMBL1871)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of an androgen receptor modulator pharmacophore based on 2-quinolinones.
van Oeveren A, Pio BA, Tegley CM, Higuchi RI, Wu M, Jones TK, Marschke KB, Negro-Vilar A, Zhi L.
Bioorg Med Chem Lett (2007) 17 : 1523 -1526
PubMed 17257838 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 11 7.05 9.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL436784 1 9.70
CHEMBL27769 STANOLONE 2.0 1 8.29
CHEMBL3706899 1 7.19
CHEMBL3706905 1 7.14
CHEMBL3706898 1 7.08
CHEMBL3706907 1 6.97
CHEMBL3706908 1 6.61
CHEMBL3706910 1 6.39
CHEMBL3706897 1 6.23
CHEMBL3706888 1 6.04
CHEMBL3706876 1 5.89

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL436784 EC50 = 0.2 nM 9.70
CHEMBL27769 STANOLONE EC50 = 5.1 nM 8.29
CHEMBL3706899 EC50 = 65.0 nM 7.19
CHEMBL3706905 EC50 = 73.0 nM 7.14
CHEMBL3706898 EC50 = 83.0 nM 7.08
CHEMBL3706907 EC50 = 108.0 nM 6.97
CHEMBL3706908 EC50 = 246.0 nM 6.61
CHEMBL3706910 EC50 = 404.0 nM 6.39
CHEMBL3706897 EC50 = 593.0 nM 6.23
CHEMBL3706888 EC50 = 905.0 nM 6.04
CHEMBL3706876 EC50 = 1300.0 nM 5.89