Assay Detail
Functional
CHEMBL887361
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human androgen receptor expressed in CV1 cells
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CV-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Discovery of an androgen receptor modulator pharmacophore based on 2-quinolinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 7.13 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3706899 | — | — | 1 | 7.85 |
| CHEMBL3706874 | — | — | 1 | 7.85 |
| CHEMBL3706908 | — | — | 1 | 7.77 |
| CHEMBL3706907 | — | — | 1 | 7.75 |
| CHEMBL3706898 | — | — | 1 | 7.72 |
| CHEMBL3706888 | — | — | 1 | 7.68 |
| CHEMBL3706910 | — | — | 1 | 7.66 |
| CHEMBL3706897 | — | — | 1 | 7.64 |
| CHEMBL385509 | — | — | 1 | 7.58 |
| CHEMBL350877 | — | — | 1 | 7.57 |
| CHEMBL3706911 | — | — | 1 | 7.57 |
| CHEMBL3706876 | — | — | 1 | 7.55 |
| CHEMBL3706877 | — | — | 1 | 7.52 |
| CHEMBL3706875 | — | — | 1 | 7.50 |
| CHEMBL3706878 | — | — | 1 | 7.46 |
| CHEMBL3706894 | — | — | 1 | 7.38 |
| CHEMBL3706909 | — | — | 1 | 7.38 |
| CHEMBL3706885 | — | — | 1 | 7.37 |
| CHEMBL3706904 | — | — | 1 | 7.30 |
| CHEMBL3706880 | — | — | 1 | 7.25 |
| CHEMBL3706889 | — | — | 1 | 7.24 |
| CHEMBL3706905 | — | — | 1 | 7.20 |
| CHEMBL3706879 | — | — | 1 | 7.17 |
| CHEMBL3706881 | — | — | 1 | 7.13 |
| CHEMBL3706896 | — | — | 1 | 7.12 |
| CHEMBL3706882 | — | — | 1 | 7.01 |
| CHEMBL3706906 | — | — | 1 | 6.96 |
| CHEMBL3706884 | — | — | 1 | 6.91 |
| CHEMBL3706886 | — | — | 1 | 6.83 |
| CHEMBL409 | BICALUTAMIDE | 4.0 | 1 | 6.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3706899 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3706874 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3706908 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3706907 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3706898 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3706888 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3706910 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3706897 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL385509 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL350877 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3706911 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3706876 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3706877 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3706875 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3706878 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL3706894 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL3706909 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL3706885 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL3706904 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3706880 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL3706889 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL3706905 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL3706879 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL3706881 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL3706896 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL3706882 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL3706906 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL3706884 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL3706886 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL409 | BICALUTAMIDE | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL3706883 | — | IC50 | = | 209.0 | nM | 6.68 |
| CHEMBL3706903 | — | IC50 | = | 216.0 | nM | 6.67 |
| CHEMBL3706891 | — | IC50 | = | 294.0 | nM | 6.53 |
| CHEMBL3706901 | — | IC50 | = | 301.0 | nM | 6.52 |
| CHEMBL3706902 | — | IC50 | = | 504.0 | nM | 6.30 |
| CHEMBL3706887 | — | IC50 | = | 507.0 | nM | 6.29 |
| CHEMBL3706895 | — | IC50 | = | 549.0 | nM | 6.26 |
| CHEMBL3706893 | — | IC50 | = | 591.0 | nM | 6.23 |
| CHEMBL3706900 | — | IC50 | = | 674.0 | nM | 6.17 |
| CHEMBL3706892 | — | IC50 | = | 1160.0 | nM | 5.94 |