Assay Detail
Binding
CHEMBL887466
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]U-69593 from rat cloned KOR
5
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Convenient synthesis and in vitro pharmacological activity of 2-thioanalogs of salvinorins A and B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.44 | 9.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL445332 | SALVINORIN A | 1.0 | 2 | 9.12 |
| CHEMBL231536 | 2-THIOSALVINORIN B | — | 1 | 7.26 |
| CHEMBL231537 | 2-EPI-2-THIOSALVINORIN A | — | 1 | 6.82 |
| CHEMBL231638 | 2-EPI-2-THIOSALVINORIN B | — | 1 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL445332 | SALVINORIN A | Ki | = | 0.75 | nM | 9.12 |
| CHEMBL445332 | SALVINORIN A | Ki | = | 18.4 | nM | 7.74 |
| CHEMBL231536 | 2-THIOSALVINORIN B | Ki | = | 54.5 | nM | 7.26 |
| CHEMBL231537 | 2-EPI-2-THIOSALVINORIN A | Ki | = | 151.0 | nM | 6.82 |
| CHEMBL231638 | 2-EPI-2-THIOSALVINORIN B | Ki | = | 546.0 | nM | 6.26 |