Assay Detail
Binding
CHEMBL887576
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Inhibition of 5-LOX in rat peritoneal leukocytes
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Indole derivatives as potent inhibitors of 5-lipoxygenase: design, synthesis, biological evaluation, and molecular modeling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.69 | 6.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL230375 | — | — | 1 | 6.13 |
| CHEMBL93 | ZILEUTON | 4.0 | 1 | 6.08 |
| CHEMBL230483 | — | — | 1 | 6.07 |
| CHEMBL388490 | — | — | 1 | 6.06 |
| CHEMBL230922 | — | — | 1 | 6.02 |
| CHEMBL389770 | — | — | 1 | 5.88 |
| CHEMBL395709 | — | — | 1 | 5.69 |
| CHEMBL230921 | — | — | 1 | 5.65 |
| CHEMBL390665 | — | — | 1 | 5.62 |
| CHEMBL230374 | — | — | 1 | 5.50 |
| CHEMBL230604 | — | — | 1 | 5.50 |
| CHEMBL230392 | — | — | 1 | 4.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL230375 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL93 | ZILEUTON | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL230483 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL388490 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL230922 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL389770 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL395709 | — | IC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL230921 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL390665 | — | IC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL230374 | — | IC50 | = | 3160.0 | nM | 5.50 |
| CHEMBL230604 | — | IC50 | = | 3170.0 | nM | 5.50 |
| CHEMBL230392 | — | IC50 | = | 74000.0 | nM | 4.13 |