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Assay Detail

CHEMBL887585

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of DPP4
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Dipeptidyl peptidase 4 (CHEMBL284)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Affinity-based ranking of ligands for DPP-4 from mixtures.
Adam GC, Meng J, Athanasopoulos J, Zhang X, Chapman KT.
Bioorg Med Chem Lett (2007) 17 : 2404 -2407
PubMed 17337342 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 6.56 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL395762 1 8.70
CHEMBL397716 1 8.10
CHEMBL427261 1 7.68
CHEMBL230839 1 7.48
CHEMBL230840 1 7.43
CHEMBL363319 1 6.92
CHEMBL230937 1 6.77
CHEMBL230938 1 6.51
CHEMBL388900 1 6.28
CHEMBL231551 1 6.27
CHEMBL231552 1 6.14
CHEMBL231653 1 6.11
CHEMBL396195 1 6.06
CHEMBL231654 1 6.00
CHEMBL410187 1 5.90
CHEMBL395546 1 5.88
CHEMBL231050 1 5.86
CHEMBL231151 1 5.84
CHEMBL396789 1 5.70
CHEMBL230095 1 5.66

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL395762 IC50 = 2.0 nM 8.70
CHEMBL397716 IC50 = 8.0 nM 8.10
CHEMBL427261 IC50 = 21.0 nM 7.68
CHEMBL230839 IC50 = 33.0 nM 7.48
CHEMBL230840 IC50 = 37.0 nM 7.43
CHEMBL363319 IC50 = 119.0 nM 6.92
CHEMBL230937 IC50 = 170.0 nM 6.77
CHEMBL230938 IC50 = 310.0 nM 6.51
CHEMBL388900 IC50 = 520.0 nM 6.28
CHEMBL231551 IC50 = 539.0 nM 6.27
CHEMBL231552 IC50 = 731.0 nM 6.14
CHEMBL231653 IC50 = 780.0 nM 6.11
CHEMBL396195 IC50 = 864.0 nM 6.06
CHEMBL231654 IC50 = 995.0 nM 6.00
CHEMBL410187 IC50 = 1247.0 nM 5.90
CHEMBL395546 IC50 = 1325.0 nM 5.88
CHEMBL231050 IC50 = 1397.0 nM 5.86
CHEMBL231151 IC50 = 1460.0 nM 5.84
CHEMBL396789 IC50 = 1995.0 nM 5.70
CHEMBL230095 IC50 = 2209.0 nM 5.66