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Compound Detail

CHEMBL230095

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C=COCC(=O)N1CCN(C(=O)C[C@H](N)Cc2ccccc2F)CC1

Basic Information

ChEMBL ID CHEMBL230095
Phase Preclinical
Structure Type MOL
InChI Key GNZMYNXUEFOUOC-OAHLLOKOSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

349.4
MW (Da)
0.92
ALogP
4
HBA
1
HBD
75.9
PSA (Ų)
0.74
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H24FN3O3
MW 349.41
Aromatic Rings 1
Heavy Atoms 25
NP-Likeness -0.94

Activity Summary

IC50 1 meas. best 5.66

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Dipeptidyl peptidase 4
CHEMBL284
IC50 5.66 5.66 2209.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Dipeptidyl peptidase 4 IC50 = 2209.0 nM 5.66 Inhibition of DPP4 17337342

Literature References

PubMed DOI Target Context # Activities
17337342 10.1016/j.bmcl.2007.02.040 Dipeptidyl peptidase 4 1

Data from ChEMBL 36 via Core Engine