Assay Detail
Functional
CHEMBL887587
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Antiproliferative activity against A375 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of pyrido[3',2':4,5]furo[3,2-d]pyrimidine derivatives as novel PI3 kinase p110alpha inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.26 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL538346 | — | — | 1 | 6.48 |
| CHEMBL3216649 | — | — | 1 | 5.41 |
| CHEMBL3216005 | — | — | 1 | 5.01 |
| CHEMBL3215760 | — | — | 1 | 4.93 |
| CHEMBL3216006 | — | — | 1 | 4.91 |
| CHEMBL537877 | — | — | 1 | 4.80 |
| CHEMBL388480 | — | — | 1 | - |
| CHEMBL534951 | — | — | 1 | - |
| CHEMBL541906 | — | — | 1 | - |
| CHEMBL390623 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL538346 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL3216649 | — | IC50 | = | 3870.0 | nM | 5.41 |
| CHEMBL3216005 | — | IC50 | = | 9670.0 | nM | 5.01 |
| CHEMBL3215760 | — | IC50 | = | 11760.0 | nM | 4.93 |
| CHEMBL3216006 | — | IC50 | = | 12320.0 | nM | 4.91 |
| CHEMBL537877 | — | IC50 | = | 15780.0 | nM | 4.80 |
| CHEMBL388480 | — | IC50 | - | — | - | |
| CHEMBL534951 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL541906 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL390623 | — | IC50 | > | 30000.0 | nM | - |