Assay Detail
Binding
CHEMBL887594
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Cyclin E/CDK2
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 2/cyclin E (CHEMBL2094126) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of pyrido[3',2':4,5]furo[3,2-d]pyrimidine derivatives as novel PI3 kinase p110alpha inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.55 | 4.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL541643 | — | — | 1 | 4.55 |
| CHEMBL98350 | LY-294002 | -1.0 | 1 | - |
| CHEMBL538346 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL541643 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL98350 | LY-294002 | IC50 | - | — | - | |
| CHEMBL538346 | — | IC50 | > | 100000.0 | nM | - |