Assay Detail
Binding
CHEMBL887659
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Displacement of [3H]CP-559440 from human CB2 receptor expressed in HEK293 cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Optimization of imidazole amide derivatives as cannabinoid-1 receptor antagonists for the treatment of obesity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 5.67 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL276312 | — | — | 1 | 6.62 |
| CHEMBL389198 | — | — | 1 | 5.96 |
| CHEMBL229967 | — | — | 1 | 5.92 |
| CHEMBL389175 | — | — | 1 | 5.64 |
| CHEMBL230800 | — | — | 1 | 5.64 |
| CHEMBL231118 | — | — | 1 | 5.57 |
| CHEMBL230801 | — | — | 1 | 5.57 |
| CHEMBL395321 | — | — | 1 | 5.29 |
| CHEMBL229914 | — | — | 1 | 5.28 |
| CHEMBL229965 | — | — | 1 | 5.20 |
| CHEMBL439375 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL276312 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL389198 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL229967 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL389175 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL230800 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL231118 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL230801 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL395321 | — | Ki | = | 5100.0 | nM | 5.29 |
| CHEMBL229914 | — | Ki | = | 5300.0 | nM | 5.28 |
| CHEMBL229965 | — | Ki | = | 6300.0 | nM | 5.20 |
| CHEMBL439375 | — | Ki | > | 1000.0 | nM | - |