Assay Detail
Binding
CHEMBL887761
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Inhibition of Plasmodium falciparum plasmepsin-2
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Additional interaction of allophenylnorstatine-containing tripeptidomimetics with malarial aspartic protease plasmepsin II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 8.11 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL411559 | — | — | 1 | 9.70 |
| CHEMBL231522 | — | — | 1 | 9.30 |
| CHEMBL440965 | — | — | 1 | 8.52 |
| CHEMBL389083 | — | — | 1 | 8.40 |
| CHEMBL230510 | — | — | 1 | 8.40 |
| CHEMBL266256 | — | — | 1 | 8.40 |
| CHEMBL394358 | — | — | 1 | 8.30 |
| CHEMBL394359 | — | — | 1 | 8.30 |
| CHEMBL411155 | — | — | 1 | 8.05 |
| CHEMBL266257 | — | — | 1 | 8.05 |
| CHEMBL410591 | — | — | 1 | 7.92 |
| CHEMBL266020 | — | — | 1 | 7.82 |
| CHEMBL411607 | — | — | 1 | 7.80 |
| CHEMBL411609 | — | — | 1 | 7.77 |
| CHEMBL411605 | — | — | 1 | 7.75 |
| CHEMBL231622 | — | — | 1 | 7.44 |
| CHEMBL414640 | — | — | 1 | 6.00 |
| CHEMBL394360 | — | — | 1 | - |
| CHEMBL411608 | — | — | 1 | - |
| CHEMBL411610 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL411559 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL231522 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL440965 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL389083 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL230510 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL266256 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL394358 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL394359 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL411155 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL266257 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL410591 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL266020 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL411607 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL411609 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL411605 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL231622 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL414640 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL394360 | — | Ki | <= | 0.1 | nM | - |
| CHEMBL411608 | — | Ki | <= | 0.1 | nM | - |
| CHEMBL411610 | — | Ki | <= | 0.1 | nM | - |