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Assay Detail

CHEMBL887898

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Functional
Inhibition of fMLP-OMe-induced chemotaxis in human neutrophils
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

2-Phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole derivatives: new potent inhibitors of fMLP-induced neutrophil chemotaxis.
Bruno O, Brullo C, Bondavalli F, Ranise A, Schenone S, Falzarano MS, Varani K, Spisani S.
Bioorg Med Chem Lett (2007) 17 : 3696 -3701
PubMed 17475488 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 7.71 10.33

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL160 CYCLOSPORINE 4.0 1 10.33
CHEMBL231427 1 9.32
CHEMBL388455 1 9.00
CHEMBL230049 1 8.94
CHEMBL231432 1 8.83
CHEMBL230051 1 8.44
CHEMBL231329 1 8.12
CHEMBL390200 1 7.57
CHEMBL231618 1 7.54
CHEMBL231529 1 6.52
CHEMBL390476 1 5.62
CHEMBL438108 1 5.05
CHEMBL433815 1 5.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL160 CYCLOSPORINE IC50 = 0.047 nM 10.33
CHEMBL231427 IC50 = 0.48 nM 9.32
CHEMBL388455 IC50 = 1.01 nM 9.00
CHEMBL230049 IC50 = 1.16 nM 8.94
CHEMBL231432 IC50 = 1.48 nM 8.83
CHEMBL230051 IC50 = 3.67 nM 8.44
CHEMBL231329 IC50 = 7.52 nM 8.12
CHEMBL390200 IC50 = 27.0 nM 7.57
CHEMBL231618 IC50 = 29.0 nM 7.54
CHEMBL231529 IC50 = 300.0 nM 6.52
CHEMBL390476 IC50 = 2400.0 nM 5.62
CHEMBL438108 IC50 = 9000.0 nM 5.05
CHEMBL433815 IC50 = 10000.0 nM 5.00